FEMA 4774 ( S9632 )

产品货号. M22734 CAS No. 1359963-68-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FEMA 4774
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FEMA 4774 是 T1R2/T1R3 的正变构调节剂。 FEMA4774在感官评价测试中显示出明显的蔗糖甜度增强作用。
产品描述

FEMA 4774 is a positive allosteric modulator of T1R2/T1R3.?FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests.
体外实验

FEMA 4774 (0-50 μM) induces a dose-dependent decrease in the EC50 value of sucrose and significantly enhances the affinity of sucrose for its binding site with an α (effect of modulator on agonist affinity) value of 30 in the human sweet receptor cells.
体内实验

FEMA 4774 (S9632) (oral gavage, 500-2000 mg/kg) does not cause a dose-dependent increase in polychromatic erythrocytes and induces micronuclei formation at dose levels up to 2000 mg/kg in Swiss albino (CD-1) mice.The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats.
同义词

S9632
通路

Others
靶点

Other Targets
受体

T1R2/T1R3
研究领域

——
适应症

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计算器

产品手册

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